Publication highlights

Orphan Nuclear Receptor NR2F6 Suppresses T Follicular Helper Cell Accumulation through Regulation of IL-21.

Olson WJ, Jakic B, Labi V, Schoeler K, Kind M, Klepsch V, Baier G, Hermann-Kleiter N. Cell Rep. 2019 Sep 10;28(11):2878-2891.e5.


Nuclear orphan receptor NR2F6 as a safeguard against experimental murine colitis.

Klepsch V, Gerner RR, Klepsch S, Olson WJ, Tilg H, Moschen AR, Baier G, Hermann-Kleiter N.

Gut. 2018 Aug;67(8):1434-1444.


Publications

Notch-mediated generation of monocyte-derived Langerhans cells: Phenotype and function.

Bellmann L, Zelle-Rieser C, Milne P, Resteu A, Tripp CH, Hermann-Kleiter N, Zaderer V, Wilflingseder D, Hörtnagl P, Theochari M, Schulze J, Rentzsch M, Del Frari B, Collin M, Rademacher C, Romani N, Stoitzner P.
J Invest Dermatol. 2020 Jun 6:S0022-202X(20)31663-8. doi: 10.1016/j.jid.2020.05.098.

A genome-wide analysis of DNA methylation identifies a novel association signal for Lp(a) concentrations in the LPA promoter.

Coassin S, Hermann-Kleiter N, Haun M, Wahl S, Wilson R, Paulweber B, Kunze S, Meitinger T, Strauch K, Peters A, Waldenberger M, Kronenberg F, Lamina C.

PLoS One. 2020 Apr 28;15(4):e0232073.

Regulation of the germinal center response by nuclear receptors and implications for autoimmune diseases.

Olson WJ, Jakic B, Hermann-Kleiter N.

FEBS J. 2020 Apr 4. doi: 10.1111/febs.15312.

Targeting the orphan nuclear receptor NR2F6 in T cells primes tumors for immune checkpoint therapy.

Klepsch V, Pommermayr M, Humer D, Brigo N, Hermann-Kleiter N, Baier G.

Cell Commun Signal. 2020 Jan 14;18(1):8.

Orphan Nuclear Receptor NR2F6 Suppresses T Follicular Helper Cell Accumulation through Regulation of IL-21.

Olson WJ, Jakic B, Labi V, Schoeler K, Kind M, Klepsch V, Baier G, Hermann-Kleiter N.

Cell Rep. 2019 Sep 10;28(11):2878-2891.e5.

Nuclear Receptors Regulate Intestinal Inflammation in the Context of IBD.

Klepsch V, Moschen AR, Tilg H, Baier G, Hermann-Kleiter N.

Front Immunol. 2019 May 14;10:1070.

CHK1 dosage in germinal center B cells controls humoral immunity.

Schoeler K, Jakic B, Heppke J, Soratroi C, Aufschnaiter A, Hermann-Kleiter N, Villunger A, Labi V.

Cell Death Differ. 2019 Mar 20. doi: 10.1038/s41418-019-0318-5

 

Fcμ receptor as a Costimulatory Molecule for T Cells.

Meryk A, Pangrazzi L, Hagen M, Hatzmann F, Jenewein B, Jakic B, Hermann-Kleiter N, Baier G, Jylhävä J, Hurme M, Trieb K, Grubeck-Loebenstein B. Cell Rep. 2019 Mar 5;26(10):2681-2691.e5.

 

Regulation of Lymphatic GM-CSF Expression by the E3 Ubiquitin Ligase Cbl-b.

Peer S, Cappellano G, Hermann-Kleiter N, Albrecht-Schgoer K, Hinterleitner R, Baier G, Gruber T.

Front Immunol. 2018 Oct 8;9:2311.

 

Nuclear Receptor NR2F6 Inhibition Potentiates Responses to PD-L1/PD-1 Cancer Immune Checkpoint Blockade. Klepsch V., Hermann-Kleiter N., Offermann A., Efremova M., Rieder D., Krogsdam A., Perner S., Tzankov A., Trajanoski Z., Wolf D. and Baier G.: Nat Commun. 2018 Apr 18;9(1):

 

Targeting immune checkpoints potentiates immunoediting and changes the dynamics of tumor evolution.

Efremova M, Rieder D, Klepsch V, Charoentong P, Finotello F, Hackl H, Hermann-Kleiter N, Löwer M, Baier G, Krogsdam A, Trajanoski Z.

Nat Commun. 2018 Jan 2;9(1):32.

 

NAD metabolism fuels human and mouse intestinal inflammation

R. R Gerner, V. Klepsch, S. Macheiner, K. Arnhard, T. E Adolph, C. Grander, V. Wieser, A. Pfister, P. Moser, N. Hermann-Kleiter, G. Baier, H. Oberacher, H.Tilg, A. R Moschen.

Gut. 2018 Oct;67(10):1813-1823.

 

Nuclear orphan receptor NR2F6 as a safeguard against experimental murine colitis.

Klepsch V, Gerner RR, Klepsch S, Olson WJ, Tilg H, Moschen AR, Baier G, Hermann-Kleiter N.

Gut. 2018 Aug;67(8):1434-1444.

Protein kinase C theta is dispensable for suppression mediated by CD25+CD4+ regulatory T cells.

Siegmund K, Thuille N, Wachowicz K, Hermann-Kleiter N, Baier G.

PLoS One. 2017 May 22;12(5):e0175463. doi: 10.1371/journal.pone.0175463. eCollection 2017.

 

Proof of Principle for a T Lymphocyte Intrinsic Function of Coronin 1A.

Siegmund K, Klepsch V, Hermann-Kleiter N, Baier G.

J Biol Chem. 2016 Oct 14;291(42):22086-22092. Epub 2016 Aug 26.


Role of PKCtheta in macrophage-mediated immune response to Salmonella typhimurium infection in mice.

Pfeifhofer-Obermair C, Albrecht-Schgoer K, Peer S, Nairz M, Siegmund K, Klepsch V, Haschka D, Thuille N, Hermann-Kleiter N, Gruber T, Weiss G, Baier G.

Cell Commun Signal. 2016 Jul 28;14(1):14. doi: 10.1186/s12964-016-0137-y.


Beyond CTLA-4 and PD-1: Orphan nuclear receptor NR2F6 as T cell signaling switch and emerging target in cancer immunotherapy.

Klepsch V, Hermann-Kleiter N, Baier G.

Immunol Lett. 2016 Oct;178:31-6. doi: 10.1016/j.imlet.2016.03.007. Epub 2016 Mar 15.


The Nuclear Orphan Receptor NR2F6 Is a Central Checkpoint for Cancer Immune Surveillance.

Hermann-Kleiter N, Klepsch V, Wallner S, Siegmund K, Klepsch S, Tuzlak S, Villunger A, Kaminski S, Pfeifhofer-Obermair C, Gruber T, Wolf D, Baier G.

Cell Rep. 2015 Sep 29;12(12):2072-85. doi: 10.1016/j.celrep.2015.08.035. Epub 2015 Sep 17.

 

Orphan nuclear receptor NR2F6 acts as an essential gatekeeper of Th17 CD4+ T cell effector functions.

Hermann-Kleiter N, Baier G.

Cell Commun Signal. 2014 Jun 12;12:38. doi: 10.1186/1478-811X-12-38. Review.

 

Protein kinase C θ regulates the phenotype of murine CD4+ Th17 cells.

Wachowicz K, Hermann-Kleiter N, Meisel M, Siegmund K, Thuille N, Baier G.

PLoS One. 2014 May 2;9(5):e96401. doi: 10.1371/journal.pone.0096401. eCollection 2014.


LAMTOR2-mediated modulation of NGF/MAPK activation kinetics during differentiation of PC12 cells.

Thauerer B, Voegele P, Hermann-Kleiter N, Thuille N, de Araujo ME, Offterdinger M, Baier G, Huber LA, Baier-Bitterlich G.PLoS One. 2014 Apr 21;9(4):e95863. doi: 10.1371/journal.pone.0095863. eCollection 2014.


Cbl-b mediates TGFβ sensitivity by downregulating inhibitory SMAD7 in primary T cells.

Gruber T, Hinterleitner R, Hermann-Kleiter N, Meisel M, Kleiter I, Wang CM, Viola A, Pfeifhofer-Obermair C, Baier G.J Mol Cell Biol. 2013 Dec;5(6):358-68. doi: 10.1093/jmcb/mjt017. Epub 2013 May 24.


PKCθ/β and CYLD are antagonistic partners in the NFκB and NFAT transactivation pathways in primary mouse CD3+ T lymphocytes.

Thuille N, Wachowicz K, Hermann-Kleiter N, Kaminski S, Fresser F, Lutz-Nicoladoni C, Leitges M, Thome M, Massoumi R, Baier G.PLoS One. 2013;8(1):e53709. doi: 10.1371/journal.pone.0053709. Epub 2013 Jan 15.


The kinase PKCα selectively upregulates interleukin-17A during Th17 cell immune responses.

Meisel M, Hermann-Kleiter N, Hinterleitner R, Gruber T, Wachowicz K, Pfeifhofer-Obermair C, Fresser F, Leitges M, Soldani C, Viola A, Kaminski S, Baier G. Immunity. 2013 Jan 24;38(1):41-52. doi: 10.1016/j.immuni.2012.09.021. Epub 2013 Jan 3.


Loss of PIDD limits NF-κB activation and cytokine production but not cell survival or transformation after DNA damage.

Bock FJ, Krumschnabel G, Manzl C, Peintner L, Tanzer MC, Hermann-Kleiter N, Baier G, Llacuna L, Yelamos J, Villunger A. Cell Death Differ. 2013 Apr;20(4):546-57. doi: 10.1038/cdd.2012.152. Epub 2012 Dec 14.


Nuclear orphan receptor NR2F6 directly antagonizes NFAT and RORγt binding to the Il17a promoter.

Hermann-Kleiter N, Meisel M, Fresser F, Thuille N, Müller M, Roth L, Katopodis A, Baier G.

J Autoimmun. 2012 Dec;39(4):428-40. doi: 10.1016/j.jaut.2012.07.007. Epub 2012 Aug 24.


Coronin 1A is an essential regulator of the TGFβ receptor/SMAD3 signaling pathway in Th17 CD4(+) T cells.

Kaminski S, Hermann-Kleiter N, Meisel M, Thuille N, Cronin S, Hara H, Fresser F, Penninger JM, Baier G.

J Autoimmun. 2011 Nov;37(3):198-208. doi: 10.1016/j.jaut.2011.05.018. Epub 2011 Jun 22.

 

NFAT pulls the strings during CD4+ T helper cell effector functions.

Hermann-Kleiter N, Baier G. Blood. 2010 Apr 15;115(15):2989-97. doi: 10.1182/blood-2009-10-233585. Epub 2010 Jan 26. Review.


PKCtheta and Itk functionally interact during primary mouse CD3+ T cell activation.

Thuille N, Lutz-Nicoladoni C, Letschka T, Hermann-Kleiter N, Heit I, Baier G.

Immunol Lett. 2009 Sep 22;126(1-2):54-9. doi: 10.1016/j.imlet.2009.07.014. Epub 2009 Aug 12.


PKC-theta modulates the strength of T cell responses by targeting Cbl-b for ubiquitination and degradation.

Gruber T, Hermann-Kleiter N, Hinterleitner R, Fresser F, Schneider R, Gastl G, Penninger JM, Baier G.

Sci Signal. 2009 Jun 23;2(76):ra30. doi: 10.1126/scisignal.2000046.


The potent protein kinase C-selective inhibitor AEB071 (sotrastaurin) represents a new class of immunosuppressive agents affecting early T-cell activation.

Evenou JP, Wagner J, Zenke G, Brinkmann V, Wagner K, Kovarik J, Welzenbach KA, Weitz-Schmidt G, Guntermann C, Towbin H, Cottens S, Kaminski S, Letschka T, Lutz-Nicoladoni C, Gruber T, Hermann-Kleiter N, Thuille N, Baier G. J Pharmacol Exp Ther. 2009 Sep;330(3):792-801. doi: 10.1124/jpet.109.153205.  Jun 2.


Lasp1 misexpression influences chondrocyte differentiation in the vertebral column.

Hermann-Kleiter N, Ghaffari-Tabrizi N, Blumer MJ, Schwarzer C, Mazur MA, Artner I.

Int J Dev Biol. 2009;53(7):983-91. doi: 10.1387/ijdb.072435nh.


PKC theta cooperates with PKC alpha in alloimmune responses of T cells in vivo.

Gruber T, Hermann-Kleiter N, Pfeifhofer-Obermair C, Lutz-Nicoladoni C, Thuille N, Letschka T, Barsig J, Baudler M, Li J, Metzler B, Nüsslein-Hildesheim B, Wagner J, Leitges M, Baier G.

Mol Immunol. 2009 Jun;46(10):2071-9. doi: 10.1016/j.molimm.2009.02.030. Epub 2009 Apr 7.


PKC-theta selectively controls the adhesion-stimulating molecule Rap1.

Letschka T, Kollmann V, Pfeifhofer-Obermair C, Lutz-Nicoladoni C, Obermair GJ, Fresser F, Leitges M, Hermann-Kleiter N, Kaminski S, Baier G.

Blood. 2008 Dec 1;112(12):4617-27. doi: 10.1182/blood-2007-11-121111. Epub 2008 Sep 16.


The nuclear orphan receptor NR2F6 suppresses lymphocyte activation and T helper 17-dependent autoimmunity.

Hermann-Kleiter N, Gruber T, Lutz-Nicoladoni C, Thuille N, Fresser F, Labi V, Schiefermeier N, Warnecke M, Huber L, Villunger A, Eichele G, Kaminski S, Baier G.

Immunity. 2008 Aug 15;29(2):205-16. doi: 10.1016/j.immuni.2008.06.008.

Defective IgG2a/2b class switching in PKC alpha-/- mice.

Pfeifhofer C, Gruber T, Letschka T, Thuille N, Lutz-Nicoladoni C, Hermann-Kleiter N, Braun U, Leitges M, Baier G.

J Immunol. 2006 May 15;176(10):6004-11.


PKCtheta and PKA are antagonistic partners in the NF-AT transactivation pathway of primary mouse CD3+ T lymphocytes.

Hermann-Kleiter N, Thuille N, Pfeifhofer C, Gruber T, Schäfer M, Zitt C, Hatzelmann A, Schudt C, Leitges M, Baier G. Blood. 2006 Jun 15;107(12):4841-8. Epub 2006 Mar 2.


Protein kinase Cepsilon is dispensable for TCR/CD3-signaling.

Gruber T, Thuille N, Hermann-Kleiter N, Leitges M, Baier G.

Mol Immunol. 2005 Feb;42(3):305-10.

 

Mutagenic transgene insertion into a region of high gene density and multiple linkage disruptions on mouse chromosome 11.

Kleiter N, Artner I, Gmachl N, Ghaffari-Tabrizi N, Kratochwil K.

Cytogenet Genome Res. 2002;97(1-2):100-5.2.

 

Genomic organization and chromosome location of the murine Rpl23 gene.

Kleiter N, Artner I, Copeland NG, Gilbert DJ, Jenkins NA, Kratochwil K.

Cytogenet Cell Genet. 2000;90(3-4):227-30.


Kleiter N, Lametschwandtner A.

Anat Embryol (Berl). 1995 Feb;191(2):145-53